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Potion of Doom in Slay the Spire 2

Slay the Spire 2 Potion

Potion of Doom

Potion of Doom is a common potion from the necrobinder pool. Apply 33 Doom.

Rarity
Common
Pool
necrobinder

Potion effect

Apply 33 Doom.

When to use it

Assign Potion of Doom a job as soon as you pick it up: save HP in the next dangerous hallway, solve an elite turn, or cover a specific boss threshold. Holding a potion forever has zero value, while using it one fight too early can leave the real check uncovered.

Potion planning

Read the potion timing guide for slot management, replacement rules, and boss preparation.