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Centennial Puzzle in Slay the Spire 2

Slay the Spire 2 Relic

Centennial Puzzle

Centennial Puzzle is a Common Relic relic from the shared pool. The first time you lose HP each combat, draw 3 cards.

Rarity
Common Relic
Pool
shared
Merchant range
149-201 gold

Relic effect

The first time you lose HP each combat, draw 3 cards.

Run value

Evaluate Centennial Puzzle by when it appears, how often its effect triggers before the next boss, and whether it changes routing or shop priorities. The strongest relic is often the one that solves the deck's immediate weakness, not the one with the highest theoretical ceiling.

Related strategy

Compare this effect with the relic guides and current patch coverage before making a build-around decision.