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Royal Poison in Slay the Spire 2

Slay the Spire 2 Relic

Royal Poison

Royal Poison is a Event Relic relic from the shared pool. At the start of each combat, lose 4 HP.

Rarity
Event Relic
Pool
shared
Merchant range
Not normally sold

Relic effect

At the start of each combat, lose 4 HP.

Run value

Evaluate Royal Poison by when it appears, how often its effect triggers before the next boss, and whether it changes routing or shop priorities. The strongest relic is often the one that solves the deck's immediate weakness, not the one with the highest theoretical ceiling.

Related strategy

Compare this effect with the relic guides and current patch coverage before making a build-around decision.