Slay the Spire 2 All Bosses Guide: Act-by-Act Prep and Counters
Prepare for every documented Slay the Spire 2 boss with an act-by-act checklist, linked move data, and the deck jobs that prevent boss losses.
Category
Boss preparation, matchup planning, scaling checks, and final campfire decisions.
How To Use This Hub
Bosses expose missing deck jobs rather than a single bad turn. A deck may need scaling for a long phase, burst block for one telegraphed attack, area damage for adds, or enough draw to find its answer before the fight accelerates.
Identify the boss, count the deck's realistic damage and defense by cycle, and assign every potion a job. The final shop and campfire should address a known matchup problem instead of following a generic upgrade priority.
Use the monster database to check HP ranges and documented moves, then read the matchup guide for sequencing and route preparation. Keep beta-only boss advice separate from the main branch.
Prepare for every documented Slay the Spire 2 boss with an act-by-act checklist, linked move data, and the deck jobs that prevent boss losses.

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